Norra Christine
From the Max-Planck-lnstitute for Experimental Medicine, Division of Clinical Neuroscience, Göttingen, Germany.
Clin EEG Neurosci. 2007 Apr;38(2):66-73. doi: 10.1177/155005940703800207.
Monoaminergic challenge tests allow investigating central nervous changes in humans under acute depletion of specific neurotransmitters (5-HT, DA, NE). Along with studies using alpha-methyl-para-tyrosine test (AMPT) and phenylalanine/tyrosine depletion test (APTD), the tryptophan depletion test (ATDT) represents the currently most established human challenge tool for the assessment of brain serotonin functioning. Neurophysiological studies in healthy and clinical samples may contribute to the search for a non-invasive and reliable biological marker of monoaminergic vulnerability or dysfunction. In the design of these studies, various biochemical and methodological aspects have to be taken into account. This article focuses on electrophysiological methodology and results of monoamine depletion studies (i.e., electroencephalography, magnetoencephalography, polysomnography, auditory evoked potentials and startle response).
单胺能激发试验可用于研究在特定神经递质（5-羟色胺、多巴胺、去甲肾上腺素）急性耗竭情况下人类中枢神经系统的变化。除了使用α-甲基对酪氨酸试验（AMPT）和苯丙氨酸/酪氨酸耗竭试验（APTD）的研究外，色氨酸耗竭试验（ATDT）是目前评估脑血清素功能最成熟的人体激发工具。对健康样本和临床样本的神经生理学研究可能有助于寻找单胺能易损性或功能障碍的非侵入性可靠生物标志物。在这些研究的设计中，必须考虑各种生化和方法学方面的因素。本文重点关注单胺耗竭研究的电生理方法和结果（即脑电图、脑磁图、多导睡眠图、听觉诱发电位和惊吓反应）。
