Gregory R B, Berry M N
Department of Medical Biochemistry, School of Medicine, Flinders University of South Australia, Adelaide.
Biochim Biophys Acta. 1991 Dec 3;1133(1):89-94. doi: 10.1016/0167-4889(91)90245-s.
Although thyroid status has been shown to influence the magnitude of the membrane potential in isolated rat-liver mitochondria, there is variation in the reported size and direction of the thyroid hormone-induced change relative to the normal state. Measurement of the mitochondrial membrane potential in intact hepatocytes isolated from hyperthyroid and euthyroid rats reveals that hyperthyroidism results in a decrease of approximately 30 mV in the magnitude of this potential relative to that in the euthyroid state. As well, the magnitude of the plasma membrane potential of hepatocytes from hyperthyroid rats is reduced by 6 mV compared with that in cells from euthyroid rats. The thyroid hormone-induced decrease in these potentials may reflect reported changes in the lipid composition of the membranes.
虽然甲状腺状态已被证明会影响离体大鼠肝线粒体膜电位的大小，但相对于正常状态，甲状腺激素诱导的变化在报道的大小和方向上存在差异。对从甲状腺功能亢进和甲状腺功能正常的大鼠分离出的完整肝细胞中线粒体膜电位的测量表明，相对于甲状腺功能正常的状态，甲状腺功能亢进会导致该电位大小降低约30mV。同样，与甲状腺功能正常的大鼠的细胞相比，甲状腺功能亢进的大鼠肝细胞的质膜电位大小降低了6mV。甲状腺激素诱导的这些电位降低可能反映了膜脂质组成的报道变化。
