Houston D K, Ding J, Nicklas B J, Harris T B, Lee J S, Nevitt M C, Rubin S M, Tylavsky F A, Kritchevsky S B
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1207, USA.
Int J Obes (Lond). 2007 Nov;31(11):1680-7. doi: 10.1038/sj.ijo.0803652. Epub 2007 May 22.
Although the association between current obesity and physical disability is well known, the cumulative effect of obesity is unknown. Using data from the Health, Aging and Body Composition study, we examined the association between weight history in young and middle adulthood and weight status in late adulthood with physical performance in late adulthood.
Longitudinal cohort study.
White and black men and women aged 70-79 years at study baseline (n=2803).
Body mass index (BMI; kg/m(2)) was calculated using recalled height at age 25 and weight at age 25 and 50 and measured height and weight at ages 70-79. Physical performance at ages 70-79 was assessed using a short physical performance battery (SPPB) and a 400-m walk test.
In this well-functioning cohort, approximately 24% of men and 8% of women reported being overweight or obese (BMI > or =25 kg/m(2)) at age 25, 51% of men and 37% of women reported being overweight or obese at age 50, and 69% of men and 66% of women were overweight or obese at ages 70-79. Men and women who were obese (BMI > or =30 kg/m(2)) at ages 25, 50 and 70-79 had significantly worse SPPB scores and 400-m walk times than those who were normal weight. Women who were overweight (BMI 25-29.9 kg/m(2)) at ages 25, 50 and 70-79 also had significantly worse physical performance. Furthermore, men and women who had a history of being overweight or obese at ages 25 or 50 had worse physical performance compared to those who were normal weight throughout or who were overweight or obese at ages 70-79 but not in midlife or earlier.
Maintaining a healthy body weight throughout adulthood may play a role in preventing or delaying the onset of physical disability.
尽管当前肥胖与身体残疾之间的关联已为人熟知，但肥胖的累积影响尚不清楚。利用健康、衰老与身体成分研究的数据，我们研究了青年和中年时期的体重史以及老年时期的体重状况与老年时期身体机能之间的关联。
纵向队列研究。
研究基线时年龄在70 - 79岁的白人和黑人男性及女性（n = 2803）。
体重指数（BMI；kg/m²）通过回忆25岁时的身高以及25岁和50岁时的体重，并测量70 - 79岁时的身高和体重来计算。70 - 79岁时的身体机能通过简短身体机能测试（SPPB）和400米步行测试进行评估。
在这个机能良好的队列中，约24%的男性和8%的女性报告在25岁时超重或肥胖（BMI≥25 kg/m²），51%的男性和37%的女性报告在50岁时超重或肥胖，69%的男性和66%的女性在70 - 79岁时超重或肥胖。在25岁、50岁以及70 - 79岁时肥胖（BMI≥30 kg/m²）的男性和女性，其SPPB得分和400米步行时间显著差于体重正常者。在25岁、50岁以及70 - 79岁时超重（BMI 25 - 29.9 kg/m²）的女性，其身体机能也显著较差。此外，与在整个成年期体重正常或在70 - 79岁时超重或肥胖但在中年或更早时期体重正常的人相比，在25岁或50岁时有超重或肥胖史的男性和女性身体机能更差。
在整个成年期保持健康体重可能在预防或延缓身体残疾的发生中发挥作用。
