Bijl Marc, Reefman Esther, Limburg Pieter C, Kallenberg Cees G M
Division of Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen. Groningen. The Netherlands.
Autoimmunity. 2007 Jun;40(4):244-8. doi: 10.1080/08916930701357125.
In the human body, every day billions of apoptotic cells are produced. Removal of these cells is necessary, to prevent the release of intracellular toxic constituents, and occurs very effectively via phagocytosis by (semi)-professional phagocytes. This elimination process occurs rapidly and without inflammation. In systemic lupus erythematosus (SLE) a disturbed elimination of apoptotic cells has been implicated in the induction and reactivation of the disease. Accumulation of apoptotic cells may result in autoantibody formation. A delayed, pro-inflammatory clearance is also thought to play a crucial role in the development of inflammatory lesions once the disease has manifested. One of the hallmarks of patients with SLE is the development of cutaneous lesions upon exposure to sunlight. In this review, we will focus on apoptotic cells, their elimination, and the consequences of a disturbed elimination of apoptotic cells on the development of UVB induced inflammatory skin lesions.
在人体中，每天会产生数十亿个凋亡细胞。清除这些细胞对于防止细胞内毒性成分的释放是必要的，并且通过（半）专业吞噬细胞的吞噬作用非常有效地发生。这个清除过程迅速且无炎症反应。在系统性红斑狼疮（SLE）中，凋亡细胞清除障碍与疾病的诱导和复发有关。凋亡细胞的积累可能导致自身抗体形成。一旦疾病显现，延迟的促炎清除也被认为在炎症病变的发展中起关键作用。SLE患者的一个特征是暴露于阳光下时会出现皮肤病变。在这篇综述中，我们将聚焦于凋亡细胞、它们的清除，以及凋亡细胞清除障碍对紫外线诱导的炎症性皮肤病变发展的影响。
