Bhat M H, Bhadada S, Dutta P, Bhansali A, Mittal B R
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Exp Clin Endocrinol Diabetes. 2007 May;115(5):331-3. doi: 10.1055/s-2007-960497.
McCune-Albright Syndrome (MAS) is a sporadic disorder characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules, and hyperfunctioning endocrinopathies. Hyperthyroidism as a manifestation of endocrine hyperfunction in MAS is uncommon. We report a patient who had polyostotic fibrous dysplasia with multiple pathological fractures and hyperthyroidism. She underwent surgery for hyperthyroidism and received pamidronate therapy with remarkable relief in bone pains and without any new fractures during her subsequent follow up of 3 years.
McCune-Albright综合征(MAS)是一种散发性疾病,其特征为多/单骨性纤维发育不良、咖啡牛奶斑和内分泌功能亢进三联征。作为MAS内分泌功能亢进表现的甲状腺功能亢进并不常见。我们报告一例患有多骨性纤维发育不良伴多发病理性骨折和甲状腺功能亢进的患者。她接受了甲状腺功能亢进手术,并接受了帕米膦酸治疗,骨痛明显缓解,在随后3年的随访中未出现任何新的骨折。