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Oseltamivir distributes to influenza virus replication sites in the middle ear and sinuses.

作者信息

Kurowski Michael, Oo Charles, Wiltshire Hugh, Barrett Joanne

机构信息

Therapia GmbH, c/o Auguste-Viktoria-Krankenhaus, Berlin, Germany.

出版信息

Clin Drug Investig. 2004;24(1):49-53. doi: 10.2165/00044011-200424010-00006.

DOI:10.2165/00044011-200424010-00006
PMID:17516690
Abstract
摘要

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本文引用的文献

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In-vitro and in-vivo efficacy of influenza neuraminidase inhibitors.流感神经氨酸酶抑制剂的体外和体内疗效
Curr Opin Infect Dis. 1998 Dec;11(6):727-32. doi: 10.1097/00001432-199812000-00013.
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Oral oseltamivir treatment of influenza in children.口服奥司他韦治疗儿童流感。
Pediatr Infect Dis J. 2001 Feb;20(2):127-33. doi: 10.1097/00006454-200102000-00002.
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Population-based study on incidence, risk factors, clinical complications and drug utilisation associated with influenza in the United Kingdom.英国基于人群的流感发病率、危险因素、临床并发症及药物使用情况研究。
奥司他韦耐药季节性甲型 H1N1 流感病毒感染患者的临床和病毒学结局：一项临床试验的结果。
Influenza Other Respir Viruses. 2012 May;6(3):153-8. doi: 10.1111/j.1750-2659.2011.00312.x. Epub 2011 Nov 26.
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Oseltamivir in seasonal, pandemic, and avian influenza: a comprehensive review of 10-years clinical experience.奥司他韦在季节性流感、大流行流感和禽流感中的应用：10 年临床经验综合评述。
Adv Ther. 2011 Nov;28(11):927-59. doi: 10.1007/s12325-011-0072-7. Epub 2011 Nov 1.
5
Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza: pharmacokinetic and pharmacodynamic characteristics.奥司他韦在季节性、禽流感 H5N1 和大流行 2009 年 A/H1N1 流感中的药代动力学和药效学特征。
Clin Pharmacokinet. 2010 Nov;49(11):741-65. doi: 10.2165/11534730-000000000-00000.
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Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations.奥司他韦的药代动力学：一种用于治疗和预防不同人群流感的口服抗病毒药物。
J Antimicrob Chemother. 2010 Apr;65 Suppl 2(Suppl 2):ii5-ii10. doi: 10.1093/jac/dkq015.
7
Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.奥司他韦及其羧酸酯在中枢神经系统中的非临床药代动力学。
Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. doi: 10.1128/AAC.01541-08. Epub 2009 Aug 31.
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Antivirals for the treatment and prevention of epidemic and pandemic influenza.用于治疗和预防流行性和大流行性流感的抗病毒药物。
Influenza Other Respir Viruses. 2007 Jan;1(1):27-34. doi: 10.1111/j.1750-2659.2006.00006.x.
9
Safety and pharmacology of oseltamivir in clinical use.临床使用中奥司他韦的安全性与药理学
Drug Saf. 2003;26(11):787-801. doi: 10.2165/00002018-200326110-00004.
Eur J Clin Microbiol Infect Dis. 2000 Nov;19(11):834-42. doi: 10.1007/s100960000376.
4
Development of a high-performance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of Ro 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine.开发一种高效液相色谱-质谱分析法，用于特异性和灵敏地定量测定抗流感药物Ro 64-0802及其前药奥司他韦在人和动物血浆及尿液中的含量。
J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):373-88. doi: 10.1016/s0378-4347(00)00300-5.
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Influenza A virus infection of human middle ear cells in vitro.
Laryngoscope. 2000 Oct;110(10 Pt 1):1739-44. doi: 10.1097/00005537-200010000-00034.
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Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group.奥司他韦治疗急性流感的疗效与安全性：一项随机对照试验。神经氨酸酶抑制剂流感治疗研究组。
Lancet. 2000 May 27;355(9218):1845-50. doi: 10.1016/s0140-6736(00)02288-1.
7
Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group.口服神经氨酸酶抑制剂奥司他韦治疗急性流感的疗效与安全性：一项随机对照试验。美国口服神经氨酸酶研究组。
JAMA. 2000 Feb 23;283(8):1016-24. doi: 10.1001/jama.283.8.1016.
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Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.前体药物奥司他韦及其活性代谢产物Ro 64-0802的临床药代动力学
Clin Pharmacokinet. 1999 Dec;37(6):471-84. doi: 10.2165/00003088-199937060-00003.
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Prevalence of various respiratory viruses in the middle ear during acute otitis media.急性中耳炎期间中耳内各种呼吸道病毒的流行情况。
N Engl J Med. 1999 Jan 28;340(4):260-4. doi: 10.1056/NEJM199901283400402.
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Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.口服流感病毒神经氨酸酶抑制剂GS 4071的前体药物可保护小鼠和雪貂免受流感感染。
Antimicrob Agents Chemother. 1998 Mar;42(3):640-6. doi: 10.1128/AAC.42.3.640.