Post David Edward
Capital Area Human Services District, Baton Rouge, LA 70806, USA.
Behav Med. 2007 Spring;33(1):11-4. doi: 10.3200/BMED.33.1.11-16.
The author relates the case study of a 38-year-old man with schizoaffective disorder (bipolar type) refractory to multiple medications. This patient had a long history of psychiatric illness and had been hospitalized at least 15 times because of aggression, hostility, and psychosis. Two separate trials of risperidone and olanzapine resulted in adverse effects, including possible neuroleptic malignant syndrome. Quetiapine, as part of combination therapy, led to substantial reductions in the patient's schizoaffective disorder symptoms and problematic behaviors. The patient tolerated quetiapine and did not experience any adverse effects. Quetiapine may be a suitable treatment option in patients with schizoaffective disorder.
作者讲述了一名38岁患有分裂情感障碍（双相型）的男性病例研究，该患者对多种药物治疗均无效。该患者有长期精神疾病史，因攻击行为、敌意和精神病症状至少住院15次。分别使用利培酮和奥氮平进行的两次试验均产生了不良反应，包括可能的抗精神病药物恶性综合征。作为联合治疗的一部分，喹硫平使该患者的分裂情感障碍症状和问题行为大幅减少。患者耐受喹硫平且未出现任何不良反应。喹硫平可能是分裂情感障碍患者的一种合适治疗选择。
