Interdomain loop mutation Asp190Cys of the tetracycline efflux transporter TetA(B) decreases affinity for substrate.
作者信息
Sapunaric Frédéric M, Levy Stuart B
出版信息
Antimicrob Agents Chemother. 2007 Aug;51(8):3036-7. doi: 10.1128/AAC.00357-07. Epub 2007 May 21.
Abstract
摘要
相似文献
1
Interdomain loop mutation Asp190Cys of the tetracycline efflux transporter TetA(B) decreases affinity for substrate.四环素外排转运蛋白TetA(B)的结构域间环突变Asp190Cys降低了对底物的亲和力。
Antimicrob Agents Chemother. 2007 Aug;51(8):3036-7. doi: 10.1128/AAC.00357-07. Epub 2007 May 21.
2
Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines.tetA(A) 四环素抗性基因的结构域间环区域突变会增加米诺环素和甘氨酰环素的外排。
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Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity.Tn10 TetA 外排转运蛋白结构域间环中的取代改变四环素抗性和底物特异性。
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Glutamate residues located within putative transmembrane helices are essential for TetA(P)-mediated tetracycline efflux.位于假定跨膜螺旋内的谷氨酸残基对于TetA(P)介导的四环素外排至关重要。
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Susceptibility of tetracyclines to Tet(a) resistance is independent of interdomain loop sequence.四环素对Tet(a)抗性的敏感性与结构域间环序列无关。
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Fe(2+)-tetracycline-mediated cleavage of the Tn10 tetracycline efflux protein TetA reveals a substrate binding site near glutamine 225 in transmembrane helix 7.亚铁离子-四环素介导的Tn10四环素外排蛋白TetA的裂解揭示了跨膜螺旋7中谷氨酰胺225附近的一个底物结合位点。
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本文引用的文献
1
Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity.Tn10 TetA 外排转运蛋白结构域间环中的取代改变四环素抗性和底物特异性。
Microbiology (Reading). 2005 Jul;151(Pt 7):2315-2322. doi: 10.1099/mic.0.27997-0.
2
TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant.通过分子置换解析的TEM1β-内酰胺酶结构及S235A突变体的优化结构。
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Second-site suppressor mutations for the serine 202 to phenylalanine substitution within the interdomain loop of the tetracycline efflux protein Tet(C).
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4
Complete cysteine-scanning mutagenesis and site-directed chemical modification of the Tn10-encoded metal-tetracycline/H+ antiporter.Tn10编码的金属四环素/H+反向转运蛋白的完全半胱氨酸扫描诱变和定点化学修饰
J Biol Chem. 2001 Jun 8;276(23):20330-9. doi: 10.1074/jbc.M007993200. Epub 2001 Feb 6.
5
Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines.tetA(A) 四环素抗性基因的结构域间环区域突变会增加米诺环素和甘氨酰环素的外排。
Microb Drug Resist. 2000 Winter;6(4):277-82. doi: 10.1089/mdr.2000.6.277.
6
Role of the charge interaction between Arg(70) and Asp(120) in the Tn10-encoded metal-tetracycline/H(+) antiporter of Escherichia coli.
J Biol Chem. 2000 Jan 7;275(1):210-4. doi: 10.1074/jbc.275.1.210.
7
Proton-dependent multidrug efflux systems.质子依赖型多药外排系统
Microbiol Rev. 1996 Dec;60(4):575-608. doi: 10.1128/mr.60.4.575-608.1996.
8
Mercaptide formed between the residue Cys70 and Hg2+ or Co2+ behaves as a functional positively charged side chain operative in the Arg70-->Cys mutant of the metal-tetracycline/H+ antiporter of Escherichia coli.在大肠杆菌金属四环素/H⁺反向转运蛋白的Arg70→Cys突变体中，残基Cys70与Hg²⁺或Co²⁺形成的硫醇盐表现为一个起作用的带正电荷的功能性侧链。
Biochemistry. 1996 Jul 23;35(29):9385-91. doi: 10.1021/bi961026z.
9
Catalytic mechanism of active-site serine beta-lactamases: role of the conserved hydroxy group of the Lys-Thr(Ser)-Gly triad.活性位点丝氨酸β-内酰胺酶的催化机制：赖氨酸-苏氨酸（丝氨酸）-甘氨酸三联体中保守羟基的作用。
Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):485-94. doi: 10.1042/bj3010485.
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