采用高效液相色谱法验证的时间杀菌法测定伏立康唑对白色念珠菌、光滑念珠菌和近平滑念珠菌分离株的活性。
Measurement of voriconazole activity against Candida albicans, C. glabrata, and C. parapsilosis isolates using time-kill methods validated by high-performance liquid chromatography.
作者信息
Li Yanjun, Nguyen M Hong, Derendorf Hartmut, Cheng Shaoji, Clancy Cornelius J
机构信息
Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.
出版信息
Antimicrob Agents Chemother. 2007 Aug;51(8):2985-7. doi: 10.1128/AAC.00308-07. Epub 2007 May 21.
Abstract
We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.
摘要
我们开发了一种高效液相色谱（HPLC）分析法，以验证伏立康唑针对白色念珠菌、光滑念珠菌和近平滑念珠菌分离株的时间杀菌和抗真菌后效应（PAFE）实验。在人血清可达到的浓度下，伏立康唑具有延长的抑菌活性，但无PAFE。HPLC证实实验是在所需的伏立康唑稳态浓度下进行的。
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