Bobin J Y, Mignotte H, Catimel G, Rivoire M, Plat R, Canelo R, Jaime G
Centre Léon-Bérard, Lyon.
Bull Cancer. 1991;78(9):819-29.
The present study is based on the data of a homogeneous series of 736 women with stage I and II operable breast cancer. The same methodology was used for treatment and follow-up. Eighty-seven patients were under 40 and 649 between 40 and 70 years ols. No statistical difference was noted between the distribution in these 2 groups regarding tumor size, the axillary or internal mammary nodal status or hormonal receptor levels. Small tumors were noted more frequently in the under 40 yr group. Overall survival was the same in both groups, independently of tumor size, axillary nodal status or hormonal receptors. Disease-free survival differed between the 2 groups: local relapse risk was 1.6 times higher for women under 40 yr, in relation to a higher frequency of conservative treatment in this group. No difference was noted for DFS in relation a tumor size, axillary nodal status of hormonal receptors.
本研究基于736例I期和II期可手术乳腺癌女性的同质系列数据。治疗和随访采用相同的方法。87例患者年龄在40岁以下，649例患者年龄在40至70岁之间。在这两组患者中，关于肿瘤大小、腋窝或内乳淋巴结状态或激素受体水平的分布未发现统计学差异。40岁以下组小肿瘤更为常见。两组的总生存率相同，与肿瘤大小、腋窝淋巴结状态或激素受体无关。两组的无病生存率有所不同：40岁以下女性的局部复发风险高出1.6倍，这与该组较高的保守治疗频率有关。在无病生存率方面，未发现与肿瘤大小、腋窝淋巴结状态或激素受体有关的差异。
