Walsh Christopher T
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
ACS Chem Biol. 2007 May 22;2(5):296-8. doi: 10.1021/cb700094s.
Diversity of scaffold structure and function is a hallmark of the >50,000 isoprenoid natural products such as taxol. Whereas most members of this class are assembled by iterative head-to-tail enzymatic joining reactions between delta2- and delta3-isopentenyl diphosphate (IPP) monomers, dimerization of two delta2-IPP molecules has now been shown to account for three additional modes of "irregular" coupling patterns at the level of C10 monoterpene scaffolds.
支架结构和功能的多样性是超过50000种类异戊二烯天然产物（如紫杉醇）的一个标志。虽然这类物质的大多数成员是通过δ2-异戊烯基二磷酸（IPP）单体之间的迭代头尾酶促连接反应组装而成，但现在已经证明，两个δ2-IPP分子的二聚化可以解释在C10单萜支架水平上另外三种“不规则”偶联模式。
