• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Organocatalytic synthesis of (2S,3R)-3-hydroxy-3-methyl-proline (OHMePro), a component of polyoxypeptins, and relatives using OHMePro itself as a catalyst.

作者信息

Yoshitomi Yayoi, Makino Kazuishi, Hamada Yasumasa

机构信息

Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

出版信息

Org Lett. 2007 Jun 21;9(13):2457-60. doi: 10.1021/ol0706004. Epub 2007 May 23.

DOI:10.1021/ol0706004
PMID:17518474
Abstract

An efficient synthesis of (2S,3R)-3-hydroxy-3-methylproline (OHMePro), a component of polyoxypeptins, and relatives was achieved, in which an intramolecular asymmetric aldol reaction of the ketoaldehyde using OHMePro itself as an organocatalyst constitutes a key step.

摘要

相似文献

1
Organocatalytic synthesis of (2S,3R)-3-hydroxy-3-methyl-proline (OHMePro), a component of polyoxypeptins, and relatives using OHMePro itself as a catalyst.
Org Lett. 2007 Jun 21;9(13):2457-60. doi: 10.1021/ol0706004. Epub 2007 May 23.
2
Studies on the synthesis of (2S,3R)-3-hydroxy-3-methylproline via C2-N bond formation.通过C2-N键形成合成(2S,3R)-3-羟基-3-甲基脯氨酸的研究。
J Org Chem. 2003 Sep 19;68(19):7479-84. doi: 10.1021/jo0349328.
3
Enantioselective synthesis of (2S,3R)-3-hydroxy-3-methylproline, a novel amino acid found in polyoxypeptins.聚肽菌素中发现的一种新型氨基酸（2S,3R）-3-羟基-3-甲基脯氨酸的对映选择性合成。
J Org Chem. 2002 Feb 8;67(3):1038-40. doi: 10.1021/jo016227+.
4
Asymmetric synthesis of alpha-amino 1,3-dithioketals from sulfinimines (N-sulfinyl imines). Synthesis of (2S,3R)-(-)-3-hydroxy-3-methylproline.由亚磺酰亚胺（N-亚磺酰基亚胺）不对称合成α-氨基-1,3-二硫代酮缩醛。(2S,3R)-(-)-3-羟基-3-甲基脯氨酸的合成。
Org Lett. 2004 Sep 16;6(19):3393-5. doi: 10.1021/ol0485971.
5
Asymmetric organocatalytic direct aldol reactions of ketones with alpha-keto acids and their application to the synthesis of 2-hydroxy-gamma-butyrolactones.酮与α-酮酸的不对称有机催化直接羟醛反应及其在2-羟基-γ-丁内酯合成中的应用。
J Org Chem. 2007 Dec 21;72(26):9905-13. doi: 10.1021/jo701868t. Epub 2007 Nov 16.
6
Two separate and distinct syntheses of stereospecifically deuteriated samples of (2S)-proline.(2S)-脯氨酸立体特异性氘代样品的两种独立且不同的合成方法。
Org Biomol Chem. 2006 Apr 21;4(8):1483-91. doi: 10.1039/b601097k. Epub 2006 Mar 9.
7
Organocatalyzed highly enantioselective direct aldol reactions of aldehydes with hydroxyacetone and fluoroacetone in aqueous media: the use of water to control regioselectivity.水相介质中有机催化醛与羟基丙酮和氟丙酮的高度对映选择性直接羟醛反应：利用水控制区域选择性
Chemistry. 2007;13(2):689-701. doi: 10.1002/chem.200600801.
8
Asymmetric aza-[2,3]-Wittig sigmatropic rearrangements: chiral auxiliary control and formal asymmetric synthesis of (2S, 3R, 4R)-4-hydroxy-3-methylproline and (-)-kainic acid.
Org Biomol Chem. 2005 Aug 7;3(15):2741-9. doi: 10.1039/b506198a. Epub 2005 Jun 30.
9
Polyoxypeptins A and B Produced by Streptomyces: Apoptosis-Inducing Cyclic Depsipeptides Containing the Novel Amino Acid (2S,3R)-3-Hydroxy-3-methylproline.
J Org Chem. 1999 Apr 30;64(9):3034-3038. doi: 10.1021/jo981512n.
10
Efficient Chemoenzymatic Synthesis of (2,3)-3-Hydroxy-3-Methylproline, a Key Fragment in Polyoxypeptin A and FR225659.聚氧肽菌素A和FR225659关键片段（2,3）-3-羟基-3-甲基脯氨酸的高效化学酶法合成
Tetrahedron. 2019 Jun 14;75(24):3253-3257. doi: 10.1016/j.tet.2019.04.009. Epub 2019 Apr 5.