Albright A Leland, Thompson Kristen, Carlos Signe, Minnigh M Beth
Department of Neurosurgery, Children's Hospital of Pittsburgh, Philadelphia, USA.
Dev Med Child Neurol. 2007 Jun;49(6):423-5. doi: 10.1111/j.1469-8749.2007.00423.x.
The aim of this study was to report concentrations of cerebrospinal fluid (CSF) baclofen in children undergoing chronic intrathecal baclofen (ITB) infusions. CSF baclofen concentrations were analyzed in 53 specimens obtained by intrathecal catheter aspiration from 43 participants (28 males, 15 females; range 3-44y, mean 16y [SD 8y 11mo]), with functioning baclofen pumps and catheters. Daily ITB doses ranged from 70 to 1395 microg per day (mean 607 microg per day [SD 363], median 575). Baclofen concentration was quantified by high-pressure liquid chromatography and confirmed by injection onto a gas chromatograph. CSF baclofen concentrations from children receiving either simple continuous or complex infusions ranged from 0.2 to 20.0 microg/ml (mean 4.64 microg/ml, median 3.3 microg/ml). CSF baclofen concentrations from children receiving simple continuous infusions ranged from 0.5 to 12.9 (mean 4.7 microg/ml, median 3.55 microg/ml). There was no correlation between ITB dosage and CSF baclofen concentration. We conclude that baclofen concentration can be measured to determine if baclofen is present in CSF. However, there appears to be no correlation between the ITB dose infused and the corresponding CSF baclofen level.
本研究的目的是报告接受慢性鞘内注射巴氯芬（ITB）治疗的儿童脑脊液中巴氯芬的浓度。对43名参与者（28名男性，15名女性；年龄范围3 - 44岁，平均16岁[标准差8岁11个月]）通过鞘内导管抽吸获得的53份样本进行了脑脊液中巴氯芬浓度分析，这些参与者的巴氯芬泵和导管功能正常。每日ITB剂量范围为每天70至1395微克（平均每天607微克[标准差363]，中位数575）。通过高压液相色谱法定量巴氯芬浓度，并通过注入气相色谱仪进行确认。接受简单持续输注或复杂输注的儿童脑脊液中巴氯芬浓度范围为0.2至20.0微克/毫升（平均4.64微克/毫升，中位数3.3微克/毫升）。接受简单持续输注的儿童脑脊液中巴氯芬浓度范围为0.5至12.9（平均4.7微克/毫升，中位数3.55微克/毫升）。ITB剂量与脑脊液中巴氯芬浓度之间无相关性。我们得出结论，可以测量巴氯芬浓度以确定脑脊液中是否存在巴氯芬。然而，注入的ITB剂量与相应的脑脊液中巴氯芬水平之间似乎没有相关性。
