脾脏CD19-CD35+B220+细胞作为滤泡树突状细胞网络形成的诱导细胞发挥作用。
Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation.
作者信息
Murakami Takaya, Chen Xin, Hase Koji, Sakamoto Ayako, Nishigaki Chie, Ohno Hiroshi
机构信息
Laboratory for Epithelial Immunobiology, Rikagaku Kenkyusho (RIKEN) Research Center for Allergy and Immunology, Yokohama, Japan.
出版信息
Blood. 2007 Aug 15;110(4):1215-24. doi: 10.1182/blood-2007-01-068387. Epub 2007 May 22.
Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle that is essential for the retention and presentation of native antigens in the form of antigen-antibody immune complexes (ICs) to B cells during secondary immune response. Although the presence of migrating precursors of FDCs has been hypothesized, their entity has not been elucidated. Here we report the identification of murine splenic CD19(-)CD11c(-)CD35(+)B220(+) cells as an inducer of FDC network formation. We demonstrated that CD19(-)-CD11c(-)CD35(+)B220(+) cells, together with stromal cells, had the remarkable ability to form lymphoid-follicle-like structures that contained B220(+)FDC-M1(+) reticular cells originally derived from CD19(-)-CD11c(-)CD35(+)B220(+) cells in the CD35(+) reticulum. Our results indicate that CD19(-)CD11c(-)CD35(+)B220(+) cells function as an inducer of FDC network formation and that the interaction between CD19(-)CD11c(-)CD35(+)B220(+) cells and stromal cells is required to initiate lymphoid follicle formation.
滤泡树突状细胞（FDCs）在淋巴滤泡中形成一个网状FDC网络，该网络对于在二次免疫应答期间以抗原-抗体免疫复合物（ICs）的形式保留天然抗原并将其呈递给B细胞至关重要。尽管已经推测存在FDCs的迁移前体，但其本质尚未阐明。在这里，我们报告将小鼠脾脏CD19(-)CD11c(-)CD35(+)B220(+)细胞鉴定为FDC网络形成的诱导物。我们证明，CD19(-)-CD11c(-)CD35(+)B220(+)细胞与基质细胞一起具有形成类淋巴滤泡结构的显著能力，这些结构包含最初源自CD19(-)-CD11c(-)CD35(+)B220(+)细胞的B220(+)FDC-M1(+)网状细胞，位于CD35(+)网状结构中。我们的结果表明，CD19(-)CD11c(-)CD35(+)B220(+)细胞作为FDC网络形成的诱导物发挥作用，并且CD19(-)CD11c(-)CD35(+)B220(+)细胞与基质细胞之间的相互作用是启动淋巴滤泡形成所必需的。
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