Martens Henk A, Bijl Marc, Kallenberg Cees G M
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
Kidney Blood Press Res. 2007;30(3):175-81. doi: 10.1159/000102986. Epub 2007 May 22.
BACKGROUND/AIM: Previous studies showed that renal hemodynamic parameters, especially the filtration fraction (FF), are decreased in patients with active lupus nephritis (LN). In this study, we evaluate the prognostic value of renal hemodynamic function tests on the renal outcome in patients with proliferative LN.
We performed a retrospective cohort study of our patients with proliferative LN from 1986 to 2005. Glomerular filtration rate (GFR) and FF before treatment were measured. Treatment failure was defined as a renal relapse or development of end-stage renal disease.
Thirty-seven patients were included. The median follow-up period was 8 years. Creatinine clearance, GFR, and FF before treatment correlated with the creatinine clearance at the end of follow-up (p = 0.001, p = 0.006, and p = 0.04, respectively). The FF was decreased in 92% of our patients, but FF and GFR did not have a prognostic value with regard to treatment failure.
Most patients with proliferative LN had a low FF. Low GFR and FF at baseline were correlated with a worse renal function at the end of follow-up, but this had no prognostic value in individual patients.
背景/目的：既往研究表明，活动性狼疮性肾炎（LN）患者的肾血流动力学参数，尤其是滤过分数（FF）降低。在本研究中，我们评估了肾血流动力学功能测试对增殖性LN患者肾脏结局的预后价值。
我们对1986年至2005年期间的增殖性LN患者进行了一项回顾性队列研究。测量治疗前的肾小球滤过率（GFR）和FF。治疗失败定义为肾脏复发或终末期肾病的发生。
纳入37例患者。中位随访期为8年。治疗前的肌酐清除率、GFR和FF与随访末期的肌酐清除率相关（分别为p = 0.001、p = 0.006和p = 0.04）。92%的患者FF降低，但FF和GFR对治疗失败无预后价值。
大多数增殖性LN患者的FF较低。基线时低GFR和FF与随访末期较差的肾功能相关，但这对个体患者无预后价值。
