Segal Michael, Avital Avi, Derevenski Andrei, Berstein Severina, Sandbank Sergio, Weizman Abraham
Flügelman's Mazra Mental Health Medical Center, Acre, Israel.
Int Clin Psychopharmacol. 2007 Jul;22(4):192-6. doi: 10.1097/YIC.0b013e3280803f3b.
The frequently seen side effect of hyperprolactinemia thought to be the 'price' paid for the antipsychotic treatment of schizophrenia. Various reports have linked the use of risperidone, an atypical antipsychotic drug, with the significant rise of prolactin levels. Thus, we set to assess possible difference between prolactin levels among schizophrenia subtypes in 45 male patients treated with stable doses (2-6 mg/day) of risperidone as antipsychotic monotherapy. All patients showed increased prolactin levels beyond the normal range, with a significant difference between the paranoid and all other groups (P<0.0001). Specifically, the paranoid patients' prolactin levels were higher than those of the schizoaffective and the disorganized ones. These results suggest that the blockade of higher dopamine activity in the paranoid schizophrenia corresponds to the prolactin increase, more than in the schizoaffective and disorganized subtypes. These findings are opposite of what was observed in the previous study of unmedicated patients.
高催乳素血症常见的副作用被认为是精神分裂症抗精神病治疗所付出的“代价”。各种报告已将非典型抗精神病药物利培酮的使用与催乳素水平的显著升高联系起来。因此，我们着手评估45例接受稳定剂量（2 - 6毫克/天）利培酮作为抗精神病单一疗法治疗的男性患者中，精神分裂症各亚型之间催乳素水平的可能差异。所有患者的催乳素水平均高于正常范围，偏执型与所有其他组之间存在显著差异（P<0.0001）。具体而言，偏执型患者的催乳素水平高于精神分裂症伴情感症状型和紊乱型患者。这些结果表明，偏执型精神分裂症中较高多巴胺活性的阻断与催乳素增加的相关性，高于精神分裂症伴情感症状型和紊乱型亚型。这些发现与之前对未用药患者的研究结果相反。
