How does the balance of excitation and inhibition shift during epileptogenesis?
作者信息
Dudek F Edward, Staley Kevin J
出版信息
Epilepsy Curr. 2007 May-Jun;7(3):86-8. doi: 10.1111/j.1535-7511.2007.00181.x.
Abstract
摘要
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How does the balance of excitation and inhibition shift during epileptogenesis?在癫痫发生过程中，兴奋与抑制的平衡是如何变化的？
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本文引用的文献
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Interictal spikes and epileptogenesis.发作间期棘波与癫痫发生。
Epilepsy Curr. 2006 Nov-Dec;6(6):199-202. doi: 10.1111/j.1535-7511.2006.00145.x.
2
Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy.颞叶癫痫中，大脑皮质对海马体的直接输入存在大量且特定的失调。
J Neurosci. 2006 Nov 15;26(46):11850-6. doi: 10.1523/JNEUROSCI.2354-06.2006.
3
Cell domain-dependent changes in the glutamatergic and GABAergic drives during epileptogenesis in the rat CA1 region.大鼠CA1区癫痫发生过程中谷氨酸能和γ-氨基丁酸能驱动的细胞区域依赖性变化。
J Physiol. 2007 Jan 1;578(Pt 1):193-211. doi: 10.1113/jphysiol.2006.119297. Epub 2006 Sep 28.
4
Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses.红藻氨酸处理后微小抑制性突触后电流（mIPSCs）和自发性抑制性突触后电流（sIPSCs）的变化：齿状颗粒细胞抑制性输入丧失及可能的代偿反应的证据
J Neurophysiol. 2005 Aug;94(2):952-60. doi: 10.1152/jn.01342.2004. Epub 2005 Mar 16.
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Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy.海藻酸诱导癫痫大鼠海马CA1锥体细胞兴奋性突触活动和局部连接性增加。
J Neurophysiol. 2004 Sep;92(3):1366-73. doi: 10.1152/jn.00131.2004. Epub 2004 Apr 14.
6
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Assessment of inhibition and epileptiform activity in the septal dentate gyrus of freely behaving rats during the first week after kainate treatment.在给予海藻酸治疗后的第一周内，对自由活动大鼠的隔区齿状回中的抑制作用和癫痫样活动进行评估。
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Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats.来自红藻氨酸处理的癫痫大鼠海马切片齿状回的电图癫痫发作和新的反复兴奋性回路。
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