α2-肾上腺素能受体激动剂的神经保护作用。

Neuroprotective effects of alpha2-adrenergic receptor agonists.

作者信息

Weber Bernd, Steinfath Markus, Scholz Jens, Bein Berthold

机构信息

Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

出版信息

Drug News Perspect. 2007 Apr;20(3):149-54. doi: 10.1358/dnp.2007.20.3.1084644.

DOI:10.1358/dnp.2007.20.3.1084644

PMID:17520091

Abstract

Alpha2-adrenergic receptor agonists exert potent analgesic and sedative/hypnotic effects. In addition, they have been shown to be neuroprotective in various experimental models, but the molecular pathways leading to these actions are still poorly defined. This review summarizes the available literature and discusses potential mechanisms of alpha2-adrenergic receptor agonist mediated neuroprotection.

摘要

α2-肾上腺素能受体激动剂具有强大的镇痛和镇静/催眠作用。此外，在各种实验模型中已证明它们具有神经保护作用，但导致这些作用的分子途径仍不清楚。这篇综述总结了现有文献，并讨论了α2-肾上腺素能受体激动剂介导神经保护的潜在机制。