Navarro Jose Francisco, Buron E, Martin-Lopez M
Department of Psychobiology, Faculty of Psychology, University of Malaga, Spain.
Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):195-8. doi: 10.1358/mf.2007.29.3.1075351.
Topiramate, an antiepileptic drug, has been found to be useful for the treatment of aggression in clinical populations. However, no studies have explored the action of this compound on aggressive behavior in laboratory animals. This work examined the effects of topiramate (10, 20, 40 and 80 mg/kg, i.p.) on agonistic interactions between male mice, using an ethopharmacological approach. Individually housed mice were exposed to anosmic "standard opponents" 30 min after drug administration. Ten minutes of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to 10 broad behavioral categories was estimated using an ethologically based analysis. Results showed that topiramate (20-80 mg/kg) produced a significant reduction of offensive behaviors (threat and attack), without affecting immobility. Digging behavior (all doses) was also significantly decreased. The antiaggressive effects of topiramate could be related to its ability for modulating positively GABA-A receptors and/or blocking AMPA subtype of glutamate receptors.
托吡酯是一种抗癫痫药物，已发现在临床人群中对攻击行为的治疗有效。然而，尚无研究探讨该化合物对实验动物攻击行为的作用。本研究采用行为药理学方法，考察了托吡酯（10、20、40和80mg/kg，腹腔注射）对雄性小鼠间争斗互动的影响。单独饲养的小鼠在给药30分钟后与无嗅觉的“标准对手”接触。在一个中性区域，将一只单独饲养的小鼠与一只无嗅觉的小鼠进行10分钟的二元互动。互动过程被录像，并使用基于行为学的分析方法估计实验对象在10个广泛行为类别上花费的累计时间。结果显示，托吡酯（20-80mg/kg）可显著减少攻击行为（威胁和攻击），且不影响静止行为。挖掘行为（所有剂量）也显著减少。托吡酯的抗攻击作用可能与其正向调节γ-氨基丁酸A受体和/或阻断谷氨酸受体的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸亚型的能力有关。
