(-)-柯诺卡潘的全合成及通过化学方法确定其绝对构型
Total synthesis of (-)-conocarpan and assignment of the absolute configuration by chemical methods.
作者信息
Clive Derrick L J, Stoffman Elia J L
机构信息
Chemistry Department, University of Alberta, Edmonton, Alberta, CanadaT6G 2G2.
出版信息
Chem Commun (Camb). 2007 Jun 7(21):2151-3. doi: 10.1039/b704211f. Epub 2007 May 1.
DOI:10.1039/b704211f
PMID:17520119
Abstract
(-)-Conocarpan (1) was synthesized by a method based on radical cyclization, and the absolute configuration was established by chemical degradation; the original 2R,3R-assignment to (+)-conocarpan should be reversed, as suggested by a later chiroptical study of model 2,3-dihydrobenzofurans.
摘要
(-)-Conocarpan（1）通过基于自由基环化的方法合成，其绝对构型通过化学降解确定；如后来对模型2,3-二氢苯并呋喃的手性光学研究所示，最初对(+)-Conocarpan的2R,3R构型归属应予以纠正。
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