Stereochemistry of rHint1 hydrolase assisted cleavage of P-N bond in nucleoside 5'-O-phosphoramidothioates.
作者信息
Krakowiak Agnieszka, Kaczmarek Renata, Baraniak Janina, Wieczorek Michał, Stec Wojciech J
机构信息
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Łódź, Poland.
出版信息
Chem Commun (Camb). 2007 Jun 7(21):2163-5. doi: 10.1039/b615160d. Epub 2007 Feb 22.
DOI:10.1039/b615160d
PMID:17520123
Abstract
The Hint-1 hydrolase assisted cleavage of the P-N bond in adenosine-5'-O-[N-(tryptophanylamide)]phosphoramidothioate proceeds with retention of configuration at the phosphorus atom which is consistent with the formation of a covalent enzyme-substrate complex.
摘要
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