Zhang Qing-hua, Qian Kun, Li Xiao-jun, Pu Jun, Wu Xiao-ting
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2007 May;10(3):212-6.
To investigate relationship between the expression of hepatocyte growth factor(HGF) and lymphatic vessel formation in gastric cancer(GC), and to further clarify the possible ways of HGF promoting GC lymphangiogenesis and lymphatic metastasis.
The expression of HGF, VEGF-C, c-Met and microlymphatic density(MLD) in tumor and non-tumor areas of 60 cases of GC and 20 cases of peptic ulcer (PU) were evaluated by immunohistochemistry. The relationships between MLD and clinicopathologic features of GC were analyzed.
The proteins of HGF, VEGF-C, and c-Met were overexpressed in GC tissues, which were significantly higher than those in normal gastric and PU tissues (P<0.001). The MLD of GC was also significant higher than those of normal gastric tissue and PU tissues (P<0.05). C-Met was expressed on enlarge lymphatic vessels in GC and PU tissues. MLD was positively correlated with the expression of HGF in GC (P<0.001).
HGF as well as VEGF-C is a lymphangiogenic factor in GC. HGF can directly or indirectly stimulate lymphangiogenesis and contribute to lymphatic metastasis in GC.
探讨肝细胞生长因子（HGF）表达与胃癌（GC）淋巴管生成之间的关系，进一步阐明HGF促进GC淋巴管生成和淋巴转移的可能途径。
采用免疫组织化学法检测60例GC患者及20例消化性溃疡（PU）患者肿瘤及非肿瘤组织中HGF、VEGF-C、c-Met的表达及微淋巴管密度（MLD）。分析GC患者MLD与临床病理特征的关系。
HGF、VEGF-C和c-Met蛋白在GC组织中高表达，显著高于正常胃组织和PU组织（P<0.001）。GC患者的MLD也显著高于正常胃组织和PU组织（P<0.05）。c-Met在GC和PU组织的扩张淋巴管中表达。GC患者MLD与HGF表达呈正相关（P<0.001）。
HGF和VEGF-C是GC中的淋巴管生成因子。HGF可直接或间接刺激淋巴管生成，促进GC淋巴转移。
