Yang Chun-kang, Zhao Wen-jin, Dai Qi-bao, Zhang Hui-hao, Zheng Wei
Department of Oncological Surgery, The First Afilliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2007 May;10(3):245-8.
To investigate the clinical characteristics,diagnosis and treatment of hepatoid adenocarcinoma of the stomach.
Clinical data of 13 hepatoid adenocarcinomas of the stomach, collected from 201 cases of gastric cancer, were analyzed retrospectively.
Of the 201 gastric carcinomas, there were 13 AFP-producing adenocarcinomas of the stomach, the positive rate was 6.5%. Morphologically, the tumor cells formed glandular, medullary and linear structures. Of the 13 hepatoid adenocarcinomas of the stomach, 10 cases were in gastric antrum and 10 cases were poorly differentiated. The metastasis rates of liver and lymph node in hepatoid adenocarcinoma of stomach were higher than those in non-hepatoid adenocarcinoma of stomach. The treatment of hepatoid adenocarcinoma of stomach depended mainly on radical resection, and adjuvant chemotherapy was needed.The prognosis of hepatoid adenocarcinoma of stomach was poor.
Hepatoid adenocarcinoma of the stomach has its own special tumor biological behavior and poor prognosis. Special attention should be paid to this disease.
探讨胃肝样腺癌的临床特征、诊断及治疗方法。
回顾性分析从201例胃癌患者中收集的13例胃肝样腺癌的临床资料。
201例胃癌中，有13例胃产甲胎蛋白腺癌，阳性率为6.5%。形态学上，肿瘤细胞形成腺管状、髓样和条索状结构。13例胃肝样腺癌中，10例位于胃窦部，10例为低分化。胃肝样腺癌的肝转移率和淋巴结转移率高于非胃肝样腺癌。胃肝样腺癌的治疗主要依靠根治性切除，且需要辅助化疗。胃肝样腺癌的预后较差。
胃肝样腺癌有其特殊的肿瘤生物学行为且预后较差。对此病应予以特别关注。
