Zheng Jiao, Zhou Hong-Hao
Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
Yao Xue Xue Bao. 2007 Jan;42(1):8-12.
Flavonoids are present in fruits, vegetables and beverages derived from plants, and in many dietary supplements or herbal remedies. A number of naturally occurring flavonoids have been shown to modulate the CYP450 system, including the induction or inhibition of these enzymes. This review focuses on the flavonoid effects on cytochrome P450 (CYP) enzyme CYP1, 2E1, 3A4 and 19. Flavonoids alter CYPs by various mechanisms, including the stimulation of gene expression via specific receptors and/or CYP protein, or mRNA stabilization and so on. But in vivo and in vitro, the effects of flavonoids are not always coincident as a result of concentrations of flavonoids, genetic and environmental factors. As well, flavonoids may interact with drugs through the induction or inhibition of their metabolism. Much attention should be paid to the metabolism interaction of the flavonoids when coadministered with other drugs.
黄酮类化合物存在于水果、蔬菜、植物来源的饮料以及许多膳食补充剂或草药中。已证实多种天然存在的黄酮类化合物可调节细胞色素P450（CYP450）系统，包括诱导或抑制这些酶。本综述聚焦于黄酮类化合物对细胞色素P450（CYP）酶CYP1、2E1、3A4和19的影响。黄酮类化合物通过多种机制改变细胞色素P450酶，包括通过特定受体和/或细胞色素P450蛋白刺激基因表达、信使核糖核酸（mRNA）稳定等。但在体内和体外，由于黄酮类化合物的浓度、遗传和环境因素，其作用效果并不总是一致。此外，黄酮类化合物可能通过诱导或抑制其他药物的代谢而与它们相互作用。当与其他药物合用时，应高度关注黄酮类化合物的代谢相互作用。
