[临床试验中的天然产物：抗菌和抗真菌剂]

[Natural products in clinical trials: antibacterial and antifungal agents].

作者信息

Han Li, Zheng Dan, Huang Xue-Shi, Yu Shi-Shan, Liang Xiao-Tian

机构信息

School of Pharmaceutical Sciences, China Medical University, Shenyang 110001, China.

出版信息

Yao Xue Xue Bao. 2007 Mar;42(3):236-44.

PMID:17520820

Abstract

Natural products have played an important role in drug discovery. Today, therapeutics from natural origin count for about 70% of the worldwide human therapeutic sales. For anti-infective treatment even higher figures are reported. This review describes antibacterial and antifungal natural products, semi-synthetic natural products and natural product derived compounds undergoing clinical evaluation or registration from 1998 to end of 2005. In addition, natural product derived drugs launched since 1998 are also discussed in this review.

摘要

天然产物在药物研发中发挥了重要作用。如今，源自天然的治疗药物约占全球人类治疗药物销售额的70%。据报道，在抗感染治疗方面这一比例甚至更高。本综述描述了1998年至2005年底正在进行临床评估或注册的抗菌和抗真菌天然产物、半合成天然产物以及天然产物衍生化合物。此外，本综述还讨论了自1998年以来上市的天然产物衍生药物。