充血性心力衰竭患者血浆免疫反应性β-内啡肽含量的变化及其临床意义。

Changes of plasma immuno-reactive beta-endorphin content in patients with congestive heart failure and their clinical significance.

作者信息

Zheng X, Zhang T H, Ding H J, Wang C H, Tan J J, Chen F J, Qin Y W

机构信息

Department of Cardiology, Changhai Hospital, Second Military Medical College, Shanghai.

出版信息

Chin Med J (Engl). 1991 Oct;104(10):814-7.

PMID:1752142

Abstract

Immunoreactive beta-endorphin (ir-beta-EP) content in plasma was measured by radioimmunoassay in 101 cardiac patients and 30 normal subjects. The results showed that plasma ir-beta-EP levels in patients of Class II (New York Heart Association Classification), Class III and Class IV were significantly higher than those in the normal group and those in patients of Class I (43.14 +/- 2.80, 54.25 +/- 4.47, 79.28 +/- 8.96 ng/L vs 24.23 +/- 2.13, and 24.98 +/- 3.35 ng/L, respectively, P less than 0.01). Plasma concentration of ir-beta-EP in patients complicated with atrial fibrillation was significantly higher than that in patients without atrial fibrillation (56.27 +/- 4.13 vs 44.66 +/- 3.41 ng/L, P less than 0.05). Ir-beta-EP contents in plasma were correlated positively to the cardiothoracic ratios (r = 0.63, P less than 0.001) and PEP/LVET ratios (r = 0.33, P less than 0.01), and were correlated negatively to the left ventricular ejection fraction and axis shortening (r = -0.41 and r = -0.39, P less than 0.001). These results indicated that plasma ir-beta-EP content may serve as a parameter in evaluating cardiac dysfunction.

摘要

采用放射免疫分析法测定了101例心脏病患者和30名正常受试者血浆中免疫反应性β-内啡肽（ir-β-EP）的含量。结果显示，纽约心脏协会分级II级、III级和IV级患者的血浆ir-β-EP水平显著高于正常组以及I级患者（分别为43.14±2.80、54.25±4.47、79.28±8.96 ng/L，而正常组及I级患者分别为24.23±2.13和24.98±3.35 ng/L，P<0.01）。合并心房颤动患者的血浆ir-β-EP浓度显著高于未合并心房颤动的患者（56.27±4.13 vs 44.66±3.41 ng/L，P<0.05）。血浆中ir-β-EP含量与心胸比率呈正相关（r=0.63，P<0.001），与PEP/LVET比率呈正相关（r=0.33，P<0.01），与左心室射血分数和轴缩短呈负相关（r=-0.41和r=-0.39，P<0.001）。这些结果表明，血浆ir-β-EP含量可作为评估心脏功能障碍的一个参数。