[脑血管疾病患者脑脊液中神经肽Y浓度的测定及其意义]

[Determination of neuropeptide Y concentration in the cerebrospinal fluid in patients with cerebrovascular diseases and its significance].

作者信息

Cao X H, Kang D X, Yang L H

机构信息

Department of Neurology, 3rd Hospital, Beijing Medical University.

出版信息

Zhonghua Nei Ke Za Zhi. 1991 Jul;30(7):429-30, 457.

PMID:1752158

Abstract

Concentration of neuropeptide Y (NPY) in the cerebrospinal fluid (CSF) of patients with cerebrovascular diseases was measured by using radioimmunoassay. The results showed that NPY concentration in CSF in patients with hemorrhagic cerebrovascular diseases (HCVD) was 4148 +/- 397.2 pg/ml, being significantly higher than the control level of 1083.7 +/- 245.8 pg/ml. While the NPY concentration in CSF of patients with ischemic cerebrovascular diseases (ICVD) was 2214 +/- 289.2 pg/ml, being not significantly different from the level in the control group. The effect of NPY in vasospasm after HCVD was preliminarily discussed.

摘要

采用放射免疫分析法测定脑血管疾病患者脑脊液中神经肽Y（NPY）的浓度。结果显示，出血性脑血管疾病（HCVD）患者脑脊液中NPY浓度为4148±397.2 pg/ml，显著高于对照组的1083.7±245.8 pg/ml。而缺血性脑血管疾病（ICVD）患者脑脊液中NPY浓度为2214±289.2 pg/ml，与对照组水平无显著差异。初步探讨了NPY在HCVD后血管痉挛中的作用。