Monfils Marie-H, Cowansage Kiriana K, LeDoux Joseph E
Center for Neural Science, 4 Washington Place, Room 809, New York University, New York, NY 10003-6621, USA.
Mol Pharmacol. 2007 Aug;72(2):235-7. doi: 10.1124/mol.107.038232. Epub 2007 May 23.
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in synaptic plasticity. In this issue of Molecular Pharmacology, Ou and Gean (p. 350) thoroughly describe the molecular cascade by which fear learning leads to an increase in BDNF expression in the lateral amygdala (LA). Calcium influx through N-methyl-D-aspartate receptors and L-type voltage-dependent calcium channels, which occurs in the LA during fear conditioning, activates protein kinase A and Ca2+/calmodulin-dependent protein kinase IV. Each induces phosphorylation of cAMP response element-binding protein, which binds to the BDNF promoter, leading to BDNF expression in the LA, and contributes to fear memory consolidation.
脑源性神经营养因子（BDNF）是神经营养因子家族的一员，在突触可塑性中发挥重要作用。在本期《分子药理学》中，Ou和Gean（第350页）详尽描述了恐惧学习导致外侧杏仁核（LA）中BDNF表达增加的分子级联反应。在恐惧条件反射过程中，LA部位通过N-甲基-D-天冬氨酸受体和L型电压依赖性钙通道发生钙内流，激活蛋白激酶A和Ca2+/钙调蛋白依赖性蛋白激酶IV。二者均诱导cAMP反应元件结合蛋白的磷酸化，该蛋白与BDNF启动子结合，导致LA中BDNF表达，并有助于恐惧记忆巩固。
