Riyami B M, Kinsella J, Pollok A J, Clark C, Stevenson R D, Reid W H, Campbell D, Gemmell C G
University Department of Anaesthesia, Glasgow Royal Infirmary, UK.
Eur J Clin Invest. 1991 Oct;21(5):485-9. doi: 10.1111/j.1365-2362.1991.tb01399.x.
In vitro migration of alveolar macrophages was studied in 24 fire victims and 19 controls; all subjects were cigarette smokers. Unstimulated (P = 0.01) and stimulated migration towards casein-(P = 0.01) and zymosan-activated serum (P = 0.002) of macrophages from smoke inhalation patients (SI) (n = 19) was increased when compared to control subjects (CS). Migration of alveolar macrophages from patients with burns without smoke inhalation (burns only, BO) was not increased. Patients with smoke inhalation and no burns (smoke only, SO) (n = 9) had increased migration when compared to controls but this was not statistically significant. Patients with smoke inhalation and burns (SB) (n = 10) had increased unstimulated migration (P = 0.01) and increased migration towards casein (P less than 0.005), ZAS (P less than 0.002) and F-met-leu-phe (P less than 0.05) when compared to controls (CS). Lavage fluid from the fire victims displayed chemotactic activity towards normal human neutrophils and its analysis for the components of the complement cascade proved positive (Clq, Clr, Factor B and C3). These data suggest that activation of alveolar macrophages may contribute to the development of pathophysiological changes in patients with smoke inhalation (SI) and particularly those with smoke inhalation and burns (SB).
对24名火灾受害者和19名对照者的肺泡巨噬细胞体外迁移进行了研究；所有受试者均为吸烟者。与对照受试者（CS）相比，烟雾吸入患者（SI）（n = 19）的巨噬细胞在未受刺激时（P = 0.01）以及向酪蛋白（P = 0.01）和酵母聚糖激活血清（P = 0.002）刺激下的迁移增加。无烟雾吸入的烧伤患者（仅烧伤，BO）的肺泡巨噬细胞迁移未增加。无烧伤的烟雾吸入患者（仅烟雾，SO）（n = 9）与对照相比迁移增加，但无统计学意义。与对照（CS）相比，烟雾吸入并烧伤患者（SB）（n = 10）的未受刺激迁移增加（P = 0.01），向酪蛋白（P < 0.005）、酵母聚糖激活血清（ZAS）（P < 0.002）和F-甲硫-亮-苯丙氨酸（P < 0.05）的迁移增加。火灾受害者的灌洗液对正常人中性粒细胞表现出趋化活性，对补体级联成分的分析呈阳性（Clq、Clr、B因子和C3）。这些数据表明，肺泡巨噬细胞的激活可能有助于烟雾吸入患者（SI），特别是烟雾吸入并烧伤患者（SB）病理生理变化的发展。
