Hafner Anita, Filipović-Grcić Jelena, Voinovich Dario, Jalsenjak Ivan
Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Drug Dev Ind Pharm. 2007 Apr;33(4):427-36. doi: 10.1080/03639040600920309.
Conventional and composed promethazine-loaded microspheres were prepared by spray drying of chitosan solution systems and double water-in-oil-in-water (W/O/W) emulsion systems, respectively. Double emulsions were prepared in two different feed concentrations, with chitosan dissolved in both water phases, and ethylcellulose dissolved in oil phase. Swelling and bioadhesive properties of the microspheres depended on the chitosan content, type and the feed concentration of spray-dried system. Results obtained suggested that better ethylcellulose microcapsules with promethazine in the chitosan matrix were formed when less concentrated emulsion systems were spray-dried. Thus, in case of such a system, with ethylcellulose/chitosan weight ratio of 1:2, prolonged promethazine release was obtained.
分别通过对壳聚糖溶液体系和双水包油包水（W/O/W）乳液体系进行喷雾干燥，制备了常规型和复合型载异丙嗪微球。双乳液在两种不同的进料浓度下制备，壳聚糖溶解于两个水相中，乙基纤维素溶解于油相中。微球的溶胀和生物黏附特性取决于壳聚糖含量、喷雾干燥体系的类型和进料浓度。所得结果表明，当对浓度较低的乳液体系进行喷雾干燥时，可在壳聚糖基质中形成含异丙嗪的性能更佳的乙基纤维素微胶囊。因此，在这样一个乙基纤维素/壳聚糖重量比为1:2的体系中，可实现异丙嗪的长效释放。
