Roze Emmanuel, Apartis Emmanuelle, Vidailhet Marie, Cochen Valérie, Beaugendre Yara, Trocello Jean-Marc, Lasjaunias Pierre, Ducreux Denis
Department of Neurology, Saint-Antoine Hospital, AP-HP, Paris, France.
CNRS UMR 7102, Paris VI University, Paris, France.
Mov Disord. 2007 Jul 30;22(10):1506-1509. doi: 10.1002/mds.21562.
Propriospinal myoclonus (PSM) is a rare movement disorder characterized by involuntary spinal-generated muscular jerks that spread rostrally and caudally to other spinally innervated muscles. Most patients have no clear etiology, and conventional MRI of the spinal cord is generally normal. Here we report the use of magnetic resonance diffusion tensor imaging (DTI) and fiber tracking to detect tract-specific abnormalities in a patient with propriospinal myoclonus. As the patient had the fragile-X premutation and antithyroid antibodies, spinal cord DTI abnormalities may be related to these conditions. Tract-specific analysis may provide new insights into the pathophysiology of propriospinal myoclonus.
脊髓性肌阵挛（PSM）是一种罕见的运动障碍，其特征为脊髓产生的不自主肌肉抽搐，可向头端和尾端扩散至其他由脊髓支配的肌肉。大多数患者病因不明，脊髓的常规磁共振成像（MRI）通常正常。在此，我们报告使用磁共振扩散张量成像（DTI）和纤维束示踪技术来检测一名脊髓性肌阵挛患者特定神经束的异常情况。由于该患者存在脆性X前突变和抗甲状腺抗体，脊髓DTI异常可能与这些情况有关。特定神经束分析可能为脊髓性肌阵挛的病理生理学提供新的见解。
