Bednarz W, Olewińiski R, Wojczys R, Czopnik P, Sutkowski K
Ist Department of General, Gastroenterological and Endcorine Surgery, Medical University of Wrocław, Poland.
Hepatogastroenterology. 2007 Mar;54(74):578-80.
BACKGROUND/AIMS: Relation between cancer of the exocrine part of the pancreas and chronic pancreatitis has not been clearly defined and the problem of carcinogens based on long-lasting chronic pancreatitis is still a matter of discussion.
The aim of the study was analysis of postoperative material of patients who in the years 1999-2003 underwent either drainage procedures (n=49) in the course of chronic pancreatitis or resectional procedures (n=36) for chronic pancreatitis or pancreatic cancer.
In the group of patients with drainage procedures pancreatic cancer was histologically detected in postoperative material (specimens collected from the wall of pancreatic pseudocyst or dilated main pancreatic duct) in 3 patients (6.1%). In the group of patients with long-lasting chronic pancreatitis who underwent a resectional procedure pancreatic cancer was postoperatively detected in 4 cases (30.7%).
Analysis of presented material confirms that long-lasting chronic pancreatitis predisposes to cancer of the exocrine part of the pancreas. This indicates that risk of pancreatic cancer should be taken into consideration in each patient with long lasting chronic pancreatitis.
背景/目的：胰腺外分泌部癌症与慢性胰腺炎之间的关系尚未明确界定，基于长期慢性胰腺炎的致癌物问题仍是一个讨论的话题。
本研究的目的是分析1999年至2003年期间接受慢性胰腺炎引流手术（n = 49）或慢性胰腺炎或胰腺癌切除手术（n = 36）患者的术后材料。
在接受引流手术的患者组中，术后材料（从胰腺假性囊肿壁或扩张的主胰管收集的标本）经组织学检测发现3例（6.1%）患有胰腺癌。在接受切除手术的长期慢性胰腺炎患者组中，术后检测到4例（30.7%）患有胰腺癌。
对所呈现材料的分析证实，长期慢性胰腺炎易引发胰腺外分泌部癌症。这表明，每一位患有长期慢性胰腺炎的患者都应考虑患胰腺癌的风险。
