由霍乱弧菌O1型ctxAB - tcpA+引起的霍乱

[Cholera caused by Vibrio cholerae O1 ctxAB- tcpA+].

作者信息

Onishchenko G G, Lomov Iu M, Moskvitina E A, Podosinnikova L S, Vodianitskaia S Iu, Prometnoĭ V I, Monakhova E V, Vodop'ianov S O, Telesmanich N R, Dudina N A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2007 Jan-Feb(1):23-9.

PMID:17523424

Abstract

Results of analysis of cholera outbreak during which V. cholerae O1 biovar El-Tor ctxAB- tcpA+ was isolated from 2 patients and 30 carriers are presented. Epidemic was caused by contamination of water source and water route of transmission. Strains identical to ones detected in humans were isolated from water of surface well in zone of water intake. Genome and VNTR-analysis of ctxAB- tcpA+ vibrios that caused outbreak in Rostov region in 2005 showed that they differed from ctxAB- tcpA- and ctxAB- tcpA+ vibrios isolated previously during and beyond of outbreaks from patients, carriers and environment and formed separate group with certain genotype. These results confirms conclusions of epidemiological analysis about imported cause of recent outbreak.

摘要

本文呈现了霍乱疫情分析结果，在此期间从2例患者和30名携带者中分离出霍乱弧菌O1生物型埃尔托ctxAB - tcpA +。疫情是由水源污染和水传播途径引起的。在取水区域的地表井水样中分离出了与在人类中检测到的菌株相同的菌株。对2005年在罗斯托夫地区引发疫情的ctxAB - tcpA +弧菌进行的基因组和VNTR分析表明，它们与之前在疫情期间及疫情之外从患者、携带者和环境中分离出的ctxAB - tcpA -和ctxAB - tcpA +弧菌不同，并形成了具有特定基因型的单独群体。这些结果证实了关于近期疫情输入性原因的流行病学分析结论。