Mavziutov A R, Bondarenko V M, Zherebtsova N Iu, Valishin D A
Zh Mikrobiol Epidemiol Immunobiol. 2007 Jan-Feb(1):89-97.
The data of pathogenicity factors of opportunistic enterobacteria, including Klebsiella, Enterobacter, Citrobacter, Proteus, Providencia and Hafnia species are submitted. The genetic control and a role of pathogenicity factors of opportunistic enterobacteria in development of diarrhea syndrome are presented. Data about adhesins, hemolysins, cytotoxic necrotizing factors and bacterial modulins are described. The characteristic of cytotonic and cytotoxic enterotoxins, including LT, ST, Shiga-like and cytolethal toxins, and mechanisms of diarrheagenic action are analysed. The role of bacterial lipopolysaccharide (endotoxin) and induction of locally synthesized proinflammatory cytokins in pathogenisis of diarrhea are discussed.
提交了机会性肠杆菌（包括克雷伯菌属、肠杆菌属、柠檬酸杆菌属、变形杆菌属、普罗威登斯菌属和哈夫尼亚菌属）致病因子的数据。介绍了机会性肠杆菌致病因子的遗传控制及其在腹泻综合征发生中的作用。描述了关于黏附素、溶血素、细胞毒性坏死因子和细菌调节蛋白的数据。分析了细胞兴奋性和细胞毒性肠毒素（包括不耐热肠毒素、耐热肠毒素、志贺样毒素和细胞致死毒素）的特性及其致泻作用机制。讨论了细菌脂多糖（内毒素）以及局部合成的促炎细胞因子的诱导在腹泻发病机制中的作用。
