Aghamohammadi A, Moazzami K, Rezaei N, Karimi A, Movahedi M, Gharagozlou M, Abdollahzade S, Pouladi N, Kouhi A, Moin M
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Laryngol Otol. 2008 Apr;122(4):409-13. doi: 10.1017/S0022215107008626. Epub 2007 May 25.
One hundred and nine patients with primary antibody deficiencies were selected in order to determine the frequency of ENT complications.
Demographic information and ENT medical histories were collected for each patient. Duration of study for each patient was divided into two periods of before diagnosis and after diagnosis and the initiation of treatment.
Eighty-two of 109 patients (75.2 per cent) experienced ENT infections during the course of the disease (63: otitis media, 75: sinusitis and nine: mastoiditis). At the time of diagnosis, 52 (47.7 per cent) out of 109 patients presented with an ENT symptom. The frequencies of episodes were 27 for sinusitis and 25 for otitis media (one complicated with mastoiditis). After immunoglobulin replacement therapy the incidence of otitis media was reduced from 1.75 before treatment to 0.39 after treatment per patient per year (p = 0.008). The incidence of sinusitis also significantly decreased from 2.38 to 0.78 (p value = 0.011).
ENT infections are common medical problems in primary antibody deficiency patients. Persistent and recurrent ENT infections should be suspected as originating from a possible underlying immunodeficiency.
选取109例原发性抗体缺陷患者，以确定耳鼻喉科并发症的发生率。
收集每位患者的人口统计学信息和耳鼻喉科病史。每位患者的研究时间分为诊断前和诊断及开始治疗后两个阶段。
109例患者中有82例（75.2%）在病程中发生了耳鼻喉科感染（63例：中耳炎，75例：鼻窦炎，9例：乳突炎）。在诊断时，109例患者中有52例（47.7%）出现了耳鼻喉科症状。发作频率为鼻窦炎27次，中耳炎25次（1例并发乳突炎）。免疫球蛋白替代治疗后，中耳炎的发病率从治疗前的每人每年1.75次降至治疗后的0.39次（p = 0.008）。鼻窦炎的发病率也从2.38显著降至0.78（p值 = 0.011）。
耳鼻喉科感染是原发性抗体缺陷患者常见的医学问题。持续性和复发性耳鼻喉科感染应怀疑可能源于潜在的免疫缺陷。
