Abbott M K, Lengyel J A
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Genetics. 1991 Nov;129(3):783-9. doi: 10.1093/genetics/129.3.783.
We have characterized the head involution defective (hid) locus which is located within the chromosomal region 75B8-C1,2. During the morphogenetic reorganization of the embryonic head region, hid+ function is necessary for the movement of the dorsal fold across the procephalon and clypeolabrum, a process that forms the frontal sac. The absence of the frontal sac in the hid mutant embryos affects the formation of the dorsal bridge and disrupts the development of the larval cephalopharyngeal skeleton. In addition to its embryonic role, this same hid function is also required during pupal development for the 360 degrees rotation of the male terminalia about the anterior-posterior body axis, and for a late step of wing blade morphogenesis. Although the abnormal wing phenotype caused by the Wrinkled (W) mutation is quite different from the one resulting from the loss-of-function hid mutations, the characterization of EMS-induced W revertants reveals that W is actually an antimorphic allele of hid.
我们已经对位于染色体区域75B8 - C1,2内的头部内卷缺陷（hid）基因座进行了表征。在胚胎头部区域的形态发生重组过程中，hid +功能对于背褶跨过前脑和唇基的移动是必需的，这一过程形成了额囊。hid突变胚胎中额囊的缺失影响背桥的形成，并破坏幼虫头咽骨骼的发育。除了其在胚胎期的作用外，在蛹发育过程中，同样的hid功能对于雄性外生殖器围绕前后身体轴的360度旋转以及翅片形态发生的后期步骤也是必需的。尽管由皱缩（W）突变引起的异常翅表型与功能丧失型hid突变导致的表型有很大不同，但对EMS诱导的W回复体的表征表明，W实际上是hid的一个反效等位基因。
