南亚裔缺血性脑卒中患者OCSP亚型中的颅内大动脉疾病
Intracranial large artery disease among OCSP subtypes in ethnic South Asian ischemic stroke patients.
作者信息
De Silva Deidre Anne, Woon Fung Peng, Pin Lee Moi, Chen Christopher P L H, Chang Hui Meng, Wong Meng Cheong
机构信息
National Neuroscience Institute, Singapore General Hospital campus, Singapore.
出版信息
J Neurol Sci. 2007 Sep 15;260(1-2):147-9. doi: 10.1016/j.jns.2007.04.020. Epub 2007 May 23.
The site of vascular stenosis correlates well with the Oxfordshire Community Stroke Project (OCSP) classification among Caucasians, but not among ethnic Chinese patients. We prospectively studied 205 consecutive ethnic South Asian ischemic stroke patients to investigate the prevalence of intracranial large artery disease determined by transcranial color-coded doppler and magnetic resonance angiography among OCSP subtypes. The distribution of OCSP subtypes was 7% total anterior circulation infarction (TACI), 17% partial anterior circulation infarction (PACI), 14% posterior circulation infarction (POCI) and 62% lacunar infarction (LACI). Significant intracranial large artery disease was common among all OCSP subtypes; 79% with TACI, 47% PACI, 65% POCI and 44% LACI. This is similar to ethnic Chinese data and is likely due to the predominance of intracranial disease over extracranial disease. Clinical axioms using OSCP subtypes based on Caucasian data may be misleading if applied to ethnic South Asians.
在白种人中，血管狭窄部位与牛津郡社区卒中项目（OCSP）分类有很好的相关性，但在华裔患者中并非如此。我们前瞻性地研究了205例连续的南亚裔缺血性卒中患者，以调查经颅彩色编码多普勒和磁共振血管造影确定的颅内大动脉疾病在OCSP各亚型中的患病率。OCSP各亚型的分布为：完全前循环梗死（TACI）占7%，部分前循环梗死（PACI）占17%，后循环梗死（POCI）占14%，腔隙性梗死（LACI）占62%。所有OCSP亚型中颅内大动脉疾病均很常见；TACI患者中占79%，PACI患者中占47%，POCI患者中占65%，LACI患者中占44%。这与华裔的数据相似，可能是由于颅内疾病比颅外疾病更常见。如果将基于白种人数据的OSCP亚型应用于南亚裔人群，临床公理可能会产生误导。
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