Ahnaou A, Nayak S, Heylen A, Ashton D, Drinkenburg W H I M
Johnson & Johnson Pharmaceutical Research & Development, A Division of Janssen Pharmaceutica N.V., B-2340 Beerse, Belgium.
Physiol Behav. 2007 Oct 22;92(3):461-7. doi: 10.1016/j.physbeh.2007.04.020. Epub 2007 Apr 22.
Sleep architecture, EEG power pattern and locomotor activity were investigated in a putative animal model of schizophrenia. The model was prepared by excitotoxic damage of the ventral hippocampus on postnatal day 7 (PD 7), after which locomotor activity and electroencephalographic (EEG) sleep profile were compared between lesioned and sham operated animals respectively, at prepuberty (postnatal day PD 35) and postpuberty (PD 56). An enhancement of locomotor activity was observed in lesioned adult PD 56, but not in juvenile PD 35 rats. Spontaneous EEG/EMG recordings during 24 h showed no major differences between both groups at PD 35 and at PD 56. However, quantitative analysis of the EEG revealed an enhancement of power in delta (delta), theta (theta) and alpha (alpha) activities in lesioned animals at PD 35 during wakefulness in both light and dark phases. At PD 56, the power in the delta and theta bands was increased during the light and dark periods in both wakefulness and non-REM sleep. These findings suggest that ventral hippocampus lesion is not associated with disturbance of sleep architecture in rats, while consistent changes were observed in the dynamic of EEG slow wave frequency domain. Thus, the data indicate that neonatal lesion of ventral hippocampus did not mimic sleep abnormalities observed in schizophrenia, however this rodent model may model some EEG features seen in schizophrenia such as a frontally pronounced slowing of the slow EEG activity in delta and theta frequency bands.
在一个假定的精神分裂症动物模型中，对睡眠结构、脑电图功率模式和运动活动进行了研究。该模型通过在出生后第7天（PD 7）对腹侧海马体进行兴奋性毒性损伤制备，之后分别在青春期前（出生后第35天，PD 35）和青春期后（PD 56）比较损伤组和假手术组动物的运动活动和脑电图（EEG）睡眠概况。在成年PD 56损伤组动物中观察到运动活动增强，但在幼年PD 35大鼠中未观察到。24小时的自发EEG/EMG记录显示，在PD 35和PD 56时两组之间没有重大差异。然而，EEG的定量分析显示，在PD 35时，损伤动物在清醒时的亮期和暗期，δ（delta）、θ（theta）和α（alpha）活动的功率增强。在PD 56时，在清醒和非快速眼动睡眠的亮期和暗期，δ和θ频段的功率均增加。这些发现表明，腹侧海马体损伤与大鼠睡眠结构紊乱无关，而在EEG慢波频域动态中观察到了一致的变化。因此，数据表明，腹侧海马体的新生期损伤并未模拟精神分裂症中观察到的睡眠异常，然而，这种啮齿动物模型可能模拟了精神分裂症中出现的一些EEG特征，如δ和θ频段中前额叶明显的慢EEG活动减慢。
