Laboratorio de Neurofisiología del Control y la Regulación, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, CP 14370 Tlalpan, México D.F.
Synapse. 2012 Aug;66(8):738-46. doi: 10.1002/syn.21563. Epub 2012 May 15.
A neonatal ventral hippocampal lesion (NVHL) in rats has been commonly used as a neurodevelopmental model to mimic schizophrenia-like behaviors. Recently, we reported that NVHL resulted in dendritic retraction and spine loss in pyramidal neurons of the prefrontal cortex (PFC). In addition, the hippocampus and PFC are important structures in the regulation of the electroencephalographic (EEG) activity. Patients with PFC lesions show deficits in the EEG activity. This study aimed to determine whether the EEG activity was altered in NVHL rats. In addition, we also analyzed the locomotor activity induced by a novel environment and exploratory behavior using the hole-board test. Consistent with the behavioral findings, the EEG analysis of the cortical regions showed that the NVHL rats displayed a lower power in cortical bands. At 1-8 Hz, 9-14 Hz, and 15-30 Hz bands, our findings showed a decrease in the absolute power of the parietal and occipital cortices recordings. In addition, the NVHL rats also showed a reduction in the exploratory behavior tested using the hole-board test. In conclusion, this study demonstrated that the EEG activity was reduced in adult NVHL rats and suggests that this may play a role in the behavioral changes observed in this neurodevelopmental model of schizophrenia.
大鼠的海马腹侧区损伤（NVHL）已被广泛用作模拟精神分裂症样行为的神经发育模型。最近，我们报道 NVHL 导致前额叶皮层（PFC）锥体神经元的树突回缩和棘突丢失。此外，海马体和 PFC 是调节脑电图（EEG）活动的重要结构。PFC 损伤的患者表现出 EEG 活动缺陷。本研究旨在确定 NVHL 大鼠的 EEG 活动是否发生改变。此外，我们还使用洞板试验分析了新环境引起的运动活动和探索行为。与行为发现一致，皮质区域的 EEG 分析表明，NVHL 大鼠在皮质带的功率较低。在 1-8 Hz、9-14 Hz 和 15-30 Hz 频段，我们的研究结果显示顶叶和枕叶皮质记录的绝对功率降低。此外，NVHL 大鼠在使用洞板试验测试的探索行为中也减少了。总之，这项研究表明，成年 NVHL 大鼠的 EEG 活动减少，并表明这可能在这种精神分裂症神经发育模型中观察到的行为变化中起作用。
