Sevilla y Ruiz A, Moya Gordillo C, Torres Lili G, Canales Perez E S
Departamento de Biologia de la Reproducción y Gineco-Endocrinología, Hospital de Gineco-Obstetricia, Centro Médico La Raza, IMSS, México, D.F.
Ginecol Obstet Mex. 1991 Oct;59:313-5.
In order to study the possible influence of circulating concentrations of estradiol (E2) and testosterone (T) on the spermatogenesis, 43 subjects, 21 to 43 years of age; 16 of them with oligoasthenozoospermia; 16 with "pure" asthenozoospermia, and 11 with normal semen study, were studied. This last group was taken as control for results evaluation and comparison. In all the cases, the presence of genitourinary infection, as well as testicular lesions and varicocele, was previously discarded. Serum concentrations of estradiol, testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL), were determined by radio-analysis, in fasting blood samples. The results are shown as average values +/- standard error (mean +/- SE). Statistical analysis of differences between the groups, was done by "t" Student test in paired samples. Patients with oligoasthenozoospermia showed a significant increase (56.9%) (less than 0.001) in estradiol circulating levels, while T, FSH, LH and PRL concentrations were below normal band, and there were not significant differences between the three groups. These results suggest that the excess of estradiol or of some of its metabolites could affect normal production of spermatozoa, maybe due to a direct effect on germinal epithelium of testicle.
为了研究循环血中雌二醇（E2）和睾酮（T）浓度对精子发生的可能影响，我们对43名年龄在21至43岁之间的受试者进行了研究；其中16人患有少弱精子症；16人患有“单纯”弱精子症；11人精液检查正常。最后一组作为结果评估和比较的对照组。在所有病例中，先前已排除泌尿生殖系统感染、睾丸病变和精索静脉曲张的存在。通过放射分析法测定空腹血样中雌二醇、睾酮、卵泡刺激素（FSH）、黄体生成素（LH）和催乳素（PRL）的血清浓度。结果以平均值±标准误差（均值±SE）表示。通过配对样本的“t”检验对各组之间的差异进行统计学分析。少弱精子症患者的循环雌二醇水平显著升高（56.9%）（P<0.001），而T、FSH、LH和PRL浓度低于正常范围，三组之间无显著差异。这些结果表明，雌二醇或其某些代谢产物的过量可能会影响精子的正常生成，这可能是由于对睾丸生精上皮的直接作用所致。
