Marret E, Bonnet F
Département d'anesthésie-réanimation, hôpital Tenon, Paris, France.
Ann Fr Anesth Reanim. 2007 Jun;26(6):535-9. doi: 10.1016/j.annfar.2007.03.014. Epub 2007 May 23.
To bring together the most recent evidences concerning the utility and safety of perioperative anti-inflammatory drug use.
References were obtained from computerised bibliographic data banks (MeSH terms: NSAIDs, coxibs, steroids, surgery, anaesthesia), followed by manual search.
NSAIDs, coxibs and steroids used alone or in association have been demonstrated to be effective for relieving postoperative pain. However, the benefits of perioperative anti-inflammatory drug use may go beyond the postoperative analgesia. In some cases, anti-inflammatory drugs have been shown to decrease the incidence of morphine side-effects, postoperative nausea and vomiting or to improve postoperative recovery. Nevertheless, NSAIDs have been found to be a risk factor of severe postoperative bleeding requiring surgical haemostasis after some surgical procedures. In contrast, coxibs have been shown to promote arterial thrombosis after others surgical procedures.
汇集有关围手术期使用抗炎药物的效用和安全性的最新证据。
通过计算机化书目数据库获取参考文献（医学主题词：非甾体抗炎药、环氧化酶-2抑制剂、类固醇、外科手术、麻醉），随后进行手工检索。
已证明单独或联合使用非甾体抗炎药、环氧化酶-2抑制剂和类固醇对缓解术后疼痛有效。然而，围手术期使用抗炎药物的益处可能不止于术后镇痛。在某些情况下，抗炎药物已显示可降低吗啡副作用、术后恶心和呕吐的发生率或改善术后恢复情况。尽管如此，已发现非甾体抗炎药是某些外科手术后需要手术止血的严重术后出血的危险因素。相比之下，环氧化酶-2抑制剂在其他外科手术后已显示会促进动脉血栓形成。
