原发性开角型青光眼患者的载脂蛋白E基因多态性
Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma.
作者信息
Zetterberg Madeleine, Tasa Gunnar, Palmér Mona Seibt, Juronen Erkki, Teesalu Pait, Blennow Kaj, Zetterberg Henrik
机构信息
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Göteborg University, Mölndal, Sweden.
出版信息
Am J Ophthalmol. 2007 Jun;143(6):1059-60. doi: 10.1016/j.ajo.2007.01.031.
PURPOSE
To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG).
DESIGN
Retrospective case-control association study.
METHODS
Patients with POAG (n = 242) and controls (n = 187) were analyzed for the APOE epsilon 2/epsilon 3/epsilon 4 polymorphisms using minisequencing technique.
RESULTS
The Alzheimer-associated APOE epsilon 4 allele had similar frequencies in the POAG group and in the control group. There was no difference between cases and controls with regard to APOE genotypes.
CONCLUSIONS
If a common pathogenic mechanism exists for the two age-related neurodegenerative diseases, POAG and AD, it does not involve APOE polymorphisms.
目的
研究原发性开角型青光眼（POAG）患者中已知会影响阿尔茨海默病（AD）风险的载脂蛋白E（APOE）基因多态性。
设计
回顾性病例对照关联研究。
方法
采用微测序技术对POAG患者（n = 242）和对照组（n = 187）进行APOE ε2/ε3/ε4基因多态性分析。
结果
与阿尔茨海默病相关的APOE ε4等位基因在POAG组和对照组中的频率相似。病例组和对照组在APOE基因型方面无差异。
结论
如果POAG和AD这两种与年龄相关的神经退行性疾病存在共同的致病机制，那么该机制不涉及APOE基因多态性。
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