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Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.

作者信息

Paumelle Réjane, Staels Bart

出版信息

Circ Res. 2007 May 25;100(10):1394-5. doi: 10.1161/01.RES.0000269334.42814.d2.

DOI:10.1161/01.RES.0000269334.42814.d2

PMID:17525375

Abstract

摘要

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Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.

作者信息

Paumelle Réjane, Staels Bart

出版信息

Circ Res. 2007 May 25;100(10):1394-5. doi: 10.1161/01.RES.0000269334.42814.d2.

DOI:10.1161/01.RES.0000269334.42814.d2

PMID:17525375

Abstract

摘要

相似文献

Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.

Circ Res. 2007 May 25;100(10):1394-5. doi: 10.1161/01.RES.0000269334.42814.d2.

Circ Res. 2007 May 25;100(10):1442-51. doi: 10.1161/01.RES.0000268411.49545.9c. Epub 2007 Apr 26.

Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway.

Circ Res. 2006 Feb 17;98(3):361-9. doi: 10.1161/01.RES.0000202706.70992.95. Epub 2006 Jan 5.

Statins downregulate myeloperoxidase gene expression in macrophages.

Biochem Biophys Res Commun. 2005 Jun 3;331(2):442-51. doi: 10.1016/j.bbrc.2005.03.204.

Cross-talk between statins and PPARalpha in cardiovascular diseases: clinical evidence and basic mechanisms.

Trends Cardiovasc Med. 2008 Apr;18(3):73-8. doi: 10.1016/j.tcm.2008.01.001.

Diabetes. 2007 Oct;56(10):2467-75. doi: 10.2337/db06-1465. Epub 2007 Jul 23.

Antiplatelet actions of statins and fibrates are mediated by PPARs.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):706-11. doi: 10.1161/ATVBAHA.108.183160. Epub 2009 Jan 15.

Int J Biochem Cell Biol. 2008;40(11):2572-82. doi: 10.1016/j.biocel.2008.05.005. Epub 2008 May 15.

Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.

Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.

Induction of macrophage elastase (MMP-12) gene expression by statins.

J Cell Physiol. 2005 Jul;204(1):139-45. doi: 10.1002/jcp.20271.

引用本文的文献

HMG-CoA Reductase Inhibitors Suppress Monosodium Urate-Induced NLRP3 Inflammasome Activation through Peroxisome Proliferator-Activated Receptor-γ Activation in THP-1 Cells.

Pharmaceuticals (Basel). 2023 Mar 31;16(4):522. doi: 10.3390/ph16040522.

Pleiotropic Effects of Atorvastatin Result in a Downregulation of the Carboxypeptidase U System (CPU, TAFIa, CPB2) in a Mouse Model of Advanced Atherosclerosis.

Pharmaceutics. 2021 Oct 19;13(10):1731. doi: 10.3390/pharmaceutics13101731.

LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL.

J Lipid Res. 2020 Jun;61(6):911-932. doi: 10.1194/jlr.P119000543. Epub 2020 Apr 15.

Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer.

Cancers (Basel). 2019 Aug 12;11(8):1153. doi: 10.3390/cancers11081153.

Statins decrease leptin expression in human white adipocytes.

Physiol Rep. 2018 Jan;6(2). doi: 10.14814/phy2.13566.

Statins: antimicrobial resistance breakers or makers?

PeerJ. 2017 Oct 24;5:e3952. doi: 10.7717/peerj.3952. eCollection 2017.

Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia.

J Lipid Res. 2016 Nov;57(11):2073-2087. doi: 10.1194/jlr.P068585. Epub 2016 Aug 31.

2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells.

Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E995-1007. doi: 10.1152/ajpendo.00267.2015. Epub 2015 Oct 20.

Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss.

J Lipid Res. 2015 Nov;56(11):2070-84. doi: 10.1194/jlr.M057547. Epub 2015 Sep 8.

Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors.

Front Aging Neurosci. 2014 Apr 23;6:71. doi: 10.3389/fnagi.2014.00071. eCollection 2014.