Giordano Thomas J
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0054, USA.
Endocr Pathol. 2006 Winter;17(4):355-63. doi: 10.1007/s12022-006-0007-z.
Adrenal cortical carcinoma is a rare but interesting endocrine tumor. Its diagnosis is usually straightforward using morphologic assessment and supplemental immunohistochemistry. However, diagnostically challenging cases exist and pathologic evaluation would benefit from the availability of adjunctive molecular testing. Here, the relevant molecular pathology of adrenal cortical tumors is reviewed with special reference to those methods (e.g., DNA microarrays) that hold promise for improved diagnosis and prognosis, and prediction of therapeutic response.
肾上腺皮质癌是一种罕见但有趣的内分泌肿瘤。通常通过形态学评估和补充免疫组化进行诊断，诊断过程较为直接。然而，存在诊断具有挑战性的病例，病理评估将受益于辅助分子检测的应用。在此，我们回顾肾上腺皮质肿瘤的相关分子病理学，特别提及那些有望改善诊断、预后及预测治疗反应的方法（如DNA微阵列）。
