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[一例使用氰基丙烯酸正丁酯成功进行内镜下硬化治疗破裂十二指肠静脉曲张的病例]

[A case of successful endoscopic injection sclerotherapy with N-butyl-2-cyanoacrylate for ruptured duodenal varices].

作者信息

Son Byoung Kwan, Sohn Joo Hyun, Chang Myung Hee, Park Yoon Kyung, Kim Tae Yeob, Jeon Yong Cheol

机构信息

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

出版信息

Korean J Gastroenterol. 2007 May;49(5):336-40.

Abstract

Duodenal varix is a rare cause of hemorrhage in patients with portal hypertension, however their rupture is serious and often life threatening. Treatments for duodenal variceal bleeding include endoscopic procedures, surgery, or interventional radiologic procedures. We report a case of duodenal varices rupture in a 45-year-old man with alcoholic liver cirrhosis who presented with melena and dizziness. Emergent upper endoscopy revealed large nodular varices with a ruptured erosion on the top in the distal second portion of duodenum. Two consecutive injections with 1.0 mL of n-butyl-2-cyanoacrylate (Histoacryl; Braun-Melsungen, Germany) mixed with 1.0 mL of lipiodol (Laboratoire-Guerbet, France) were performed intravariceally and achieved successful hemostasis. This suggests that endoscopic injection sclerotherapy with histoacryl may be an effective therapeutic option for the control of ruptured duodenal variceal bleeding.

摘要

十二指肠静脉曲张是门静脉高压患者出血的罕见原因,然而其破裂后果严重,常危及生命。十二指肠静脉曲张出血的治疗方法包括内镜手术、外科手术或介入放射学手术。我们报告一例45岁酒精性肝硬化男性患者发生十二指肠静脉曲张破裂,表现为黑便和头晕。急诊上消化道内镜检查发现十二指肠远端第二部有大的结节状静脉曲张,顶部有破裂糜烂。在静脉曲张内连续两次注射1.0 mL正丁基-2-氰基丙烯酸酯(Histoacryl;德国布劳恩-梅尔松根公司)与1.0 mL碘油(法国Laboratoire-Guerbet公司)混合液,成功实现止血。这表明用Histoacryl进行内镜注射硬化疗法可能是控制破裂十二指肠静脉曲张出血的一种有效治疗选择。

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