Rubattu S, Evangelista A, Barbato D, Barba G, Stanzione R, Iacone R, Volpe M, Strazzullo P
J Hum Hypertens. 2007 Oct;21(10):822-4. doi: 10.1038/sj.jhh.1002228. Epub 2007 May 24.
Previous evidence supports a role of atrial natriuretic peptide (ANP) as a candidate gene for hypertension. We characterized an ANP gene promoter variant, which has been associated with lower peptide levels, in a sample of young male subjects from Southern Italy (n=395, mean age=35.2+/-2 years) followed up for 28 years. In this cohort, the ANP gene variant was associated with early blood pressure increase and predisposition to develop hypertension.
先前的证据支持心房利钠肽（ANP）作为高血压候选基因的作用。我们在来自意大利南部的年轻男性受试者样本（n = 395，平均年龄 = 35.2±2岁）中对一种与较低肽水平相关的ANP基因启动子变体进行了特征分析，并随访了28年。在这个队列中，ANP基因变体与早期血压升高和患高血压的易感性有关。
