Putterman C, Livshitz T
Dept. of Internal Medicine A, Hadassah University Hospital, Ein Kerem, Jerusalem.
Harefuah. 1991 Aug;121(3-4):92-3.
Captopril is widely used for congestive heart failure and arterial hypertension. Its main side effects are cough, neutropenia, and renal injury. Liver dysfunction has rarely been described. We present a 71-year-old man with an acute myocardial infarction who developed high fever and progressive disturbance of liver function tests, hepatocellular and cholestatic, after beginning captopril. When other, more likely causes for his condition were ruled out, captopril was discontinued and the fever and liver dysfunction then quickly resolved. We recommend periodic laboratory follow-up in patients treated with angiotensin-converting enzyme inhibitors.
卡托普利广泛用于治疗充血性心力衰竭和动脉高血压。其主要副作用为咳嗽、中性粒细胞减少和肾损伤。肝功能障碍鲜有报道。我们报告一名71岁急性心肌梗死男性患者，在开始使用卡托普利后出现高热及肝功能检查进行性异常，表现为肝细胞性和胆汁淤积性。当排除了其他更可能导致其病情的原因后，停用卡托普利，发热及肝功能障碍随后迅速缓解。我们建议对接受血管紧张素转换酶抑制剂治疗的患者进行定期实验室随访。
