Lun Samantha W M, Wong C K, Ko Fanny W S, Hui David S C, Lam Christopher W K
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
J Clin Immunol. 2007 Jul;27(4):430-7. doi: 10.1007/s10875-007-9093-z. Epub 2007 May 25.
CD26, which is a costimulatory molecule and peptidase, is responsible for the degradation of interferon (IFN)-gamma-induced chemokines. To elucidate the immunopathological role of CD26 in allergic asthma, we investigated plasma soluble CD26 (sCD26) concentration and its cell surface expression on lymphocytes, monocytes, CD4+ T helper, CD8+ T suppressor plus cytotoxic T, invariant natural killer T (iNKT), and CD19+ B lymphocytes in allergic asthmatic patients. Plasma sCD26 was significantly elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface expression of CD26 was significantly up-regulated on lymphocytes, especially on CD4+ and iNKT lymphocytes (all P < 0.05), but not on other cell types. Significant positive correlations were found between sCD26 and the percentage of eosinophils, Th2-related chemokines CCL5 and CCL22, and costimulatory molecule sCTLA-4 (all P < 0.05). In conclusion, the aberrant expression of CD26 may contribute to the inflammatory process and Th2 predominance in the immunopathogenesis of allergic asthma.
CD26是一种共刺激分子和肽酶，负责干扰素（IFN）-γ诱导的趋化因子的降解。为了阐明CD26在过敏性哮喘中的免疫病理作用，我们研究了过敏性哮喘患者血浆可溶性CD26（sCD26）浓度及其在淋巴细胞、单核细胞、CD4 +辅助性T细胞、CD8 +抑制性加细胞毒性T细胞、不变自然杀伤T（iNKT）细胞和CD19 + B淋巴细胞上的细胞表面表达。无论是否接受吸入性糖皮质激素治疗，哮喘患者血浆sCD26均显著升高（所有P < 0.05）。CD26的细胞表面表达在淋巴细胞上显著上调，尤其是在CD4 +和iNKT淋巴细胞上（所有P < 0.05），但在其他细胞类型上未上调。sCD26与嗜酸性粒细胞百分比、Th2相关趋化因子CCL5和CCL22以及共刺激分子sCTLA-4之间存在显著正相关（所有P < 0.05）。总之，CD26的异常表达可能在过敏性哮喘的免疫发病机制中促成炎症过程和Th2优势。
