一项关于重度抑郁症患者在多项任务中前额叶脑激活的功能磁共振成像研究。
An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder.
作者信息
Fitzgerald Paul B, Srithiran Anusha, Benitez Jessica, Daskalakis Zafiris Z, Oxley Tom J, Kulkarni Jayashri, Egan Gary F
机构信息
Department of Psychological Medicine, Alfred Psychiatry Research Centre, The Alfred and Monash University, Melbourne, Victoria, Australia.
出版信息
Hum Brain Mapp. 2008 Apr;29(4):490-501. doi: 10.1002/hbm.20414.
Abstract
OBJECTIVE
Previous research has provided conflicting information regarding the pattern of brain activation associated with cognitive performance in depressed people. We aimed to assess brain activation related to cognitive performance during planning and working memory tasks.
METHOD
fMRI scans were conducted using a modified Tower of London task and a 2-back task in 13 patients with major depressive disorder and a matched control group.
RESULTS
Task performance was impaired in the depressed group on the Tower of London task but there were no differences between the groups in task performance on the n-back task. The patient group showed widespread increased brain activation in both tasks. There was considerable overlap in increased activation between the two tasks, especially in right prefrontal cortical regions.
CONCLUSIONS
Patients with depression exhibit increased brain activation, especially in right prefrontal regions, across several types of cognitive task activity. Patients with depression may recruit greater brain regions to achieve similar or even poorer task performance than control subjects.
摘要
目的
先前的研究提供了关于抑郁症患者认知表现相关脑激活模式的相互矛盾的信息。我们旨在评估在计划和工作记忆任务期间与认知表现相关的脑激活情况。
方法
对13名重度抑郁症患者和一个匹配的对照组进行功能磁共振成像（fMRI）扫描，使用改良的伦敦塔任务和2-back任务。
结果
抑郁症组在伦敦塔任务中的任务表现受损，但在n-back任务中的任务表现两组之间没有差异。患者组在两项任务中均显示出广泛的脑激活增加。两项任务之间激活增加有相当大的重叠，特别是在右前额叶皮质区域。
结论
抑郁症患者在多种类型的认知任务活动中表现出脑激活增加，特别是在右前额叶区域。与对照组相比，抑郁症患者可能会调动更大的脑区来实现相似甚至更差的任务表现。
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