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[改善肾上腺皮质功能对某些疾病康复的重要作用]

[Important action of improving adrenocortical function for certain diseases recovery].

作者信息

Shen Zi-yin, Dong Jing-cheng, Cai Ding-fang

机构信息

Institute of Integrated Traditional Chinese Medicine and Western Medicine, Huashan Hospital, Fudan University, Shanghai.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Apr;27(4):364-7.

Abstract

It has been found that the hypofunction status of hypothalamus-pituitary-adrenal (HPA) axis exists in patients with Shen-yang deficiency syndrome of TCM, also presents in most asthma patients. Seasonal attack of asthma can be prevented with Shen-tonifying drugs by improving adrenocortical function. Since patients subject to long-term glucocorticoids display hypofunction condition of HPA axis, Shen-tonifying drugs should be helpful to gluocorticoid withdrawal for getting higher success rate. Basic researches also indicated that the activating of adrenocortical stem cells and promoting regeneration of adrenal cortex is one of the mechanisms underlying improvement of adrenocortical function. Series of research showed that hypofunction of adrenocortex is the general pathological change in some diseases, so, Shen-tonifying drugs act a part in unitarily modulating the adrenocortical function, to get the therapeutic effect of both regulating the whole and improving the local.

摘要

研究发现,中医肾阳虚证患者存在下丘脑 - 垂体 - 肾上腺(HPA)轴功能低下状态,多数哮喘患者也有此表现。补肾药物可通过改善肾上腺皮质功能预防哮喘季节性发作。由于长期使用糖皮质激素的患者存在HPA轴功能低下情况,补肾药物应有助于糖皮质激素撤减,以提高成功率。基础研究还表明,激活肾上腺皮质干细胞和促进肾上腺皮质再生是改善肾上腺皮质功能的机制之一。系列研究显示,肾上腺皮质功能低下是某些疾病的共同病理变化,因此,补肾药物在整体调节肾上腺皮质功能方面发挥作用,以达到整体调理和局部改善的治疗效果。

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